Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.33 |
| ▸ | DNA2 | P51530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250224 | 0.85 | CYP1A2 (0.42) | CYP1A2HSD17B10BRD4CA12CA9 | |
| SCHEMBL3249171 | 0.83 | CHEK1 (0.51) | CYP1A2HSD17B10BRD4KDM4ECHEK1 | |
| SCHEMBL3250871 | 0.81 | BRD4 (0.40) | CYP1A2HSD17B10BRD4CHEK1 | |
| SCHEMBL4172089 | 0.81 | HPGD (0.40) | BRD4CA12CA9PARP1TNKS | |
| SCHEMBL3251105 | 0.81 | BRD4 (0.62) | CYP1A2BRD4CA12CA9KDM4E | |
| SCHEMBL3249236 | 0.79 | BRD4 (0.60) | BRD4 | |
| SCHEMBL3242527 | 0.79 | CYP1A2 (0.37) | CYP1A2HSD17B10BRD4CA12CA9 | |
| SCHEMBL3243089 | 0.79 | CYP1A2 (0.45) | CYP1A2HSD17B10F7F3KDM4E | |
| SCHEMBL3251991 | 0.79 | KDM4E (0.58) | CYP1A2HSD17B10F7F3KDM4E | |
| SCHEMBL3241773 | 0.79 | NGFR (0.49) | CYP1A2HSD17B10CA12CA9F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |