Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.34 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.33 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.33 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4166962 | 0.87 | HPGD (0.42) | HPGDCYP2C19GPR17CA12CA9 | |
| Hydrochloric Acid SCHEMBL4168323 | 0.86 | HPGD (0.41) | HPGDCYP2C19GPR17CA12CA9 | |
| SCHEMBL3246300 | 0.85 | HPGD (0.47) | HPGDCYP2C19CA12CA9AKT2 | |
| SCHEMBL4159606 | 0.83 | SPR (0.46) | HPGDCYP2C19GPR17CA12CA9 | |
| SCHEMBL3245758 | 0.82 | BRD4 (0.56) | BRD4PARP1TNKSPARP15PARP14 | |
| SCHEMBL4157962 | 0.82 | HPGD (0.40) | HPGDCYP2C19GPR17CA12CA9 | |
| SCHEMBL4160621 | 0.81 | MPO (0.49) | HPGDCYP2C19GPR17SERPINE1 | |
| SCHEMBL3245032 | 0.81 | CYP1A2 (0.40) | CA12CA9BRD4PARP1TNKS | |
| SCHEMBL4155432 | 0.81 | CYP2C19 (0.44) | HPGDCYP2C19GPR17PARP1 | |
| SCHEMBL4169910 | 0.81 | HPGD (0.44) | HPGDCYP2C19GPR17PARP1SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | disclosed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | MAP3K1, MAP3K2, MAP3K7 | HPGD 882/4885CYP2C19 4277/4885GPR17 2461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.