SCHEMBL324525

SCHEMBL324525

CS(=O)(=O)Oc1ccc(C(=O)CBr)c(F)c1.O=C(CBr)c1cccc(OCc2ccccc2)c1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.48
PTPN1 P18031 1/20 0.47
NR4A2 P43354 3/20 0.47
MRGPRX4 Q96LA9 1/20 0.45
PARP15 Q460N3 1/20 0.44
PARP10 Q53GL7 1/20 0.44
SMPD1 P17405 1/20 0.44
KMT2A Q03164 1/20 0.44
SRD5A2 P31213 1/20 0.43
MAOA P21397 1/20 0.42
CYP19A1 P11511 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5460586 0.83 PARP10 (0.56) MAOBNR4A2MRGPRX4PARP15PARP10
SCHEMBL1438387 0.81 ALDH1A1 (0.40) MAOBPARP15PARP10KMT2AMAOA
SCHEMBL1438839 0.80 NR4A2 (0.72) MAOBPTPN1NR4A2MRGPRX4SMPD1
SCHEMBL31487931 0.75 MAOB (0.63) MAOBNR4A2SMPD1KMT2AMAOA
SCHEMBL27635587 0.75 MAOB (0.63) MAOBNR4A2SMPD1KMT2AMAOA
SCHEMBL31487932 0.73 MAOB (0.61) MAOBNR4A2SMPD1KMT2AMAOA
SCHEMBL2997270 0.72 MAOB (0.62) MAOBNR4A2MRGPRX4PARP15PARP10
SCHEMBL1437602 0.72 MAOB (0.58) MAOBNR4A2MRGPRX4PARP10SRD5A2
SCHEMBL4473413 0.71 MAOB (0.61) MAOBNR4A2PARP15PARP10KMT2A
SCHEMBL1555449 0.71 MAOB (0.79) MAOBPARP15PARP10MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2590954-B1 BISARYL (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS ABBVIE BV (NL) 2016-04-13 EP disclosed
EP-2590954-A1 BISARYL (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS ABBVIE B.V. (NL) 2013-05-15 EP disclosed
WO-2012004375-A1 BISARYL (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS ABBOTT HEALTHCARE PRODUCTS B.V. (NL) 2012-01-12 WO disclosed