Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019251 | 1.00 | EPHX1 (0.33) | EPHX1HTTLMNASIGMAR1ALDH1A1 | |
| SCHEMBL13316359 | 1.00 | EPHX1 (0.33) | EPHX1HTTLMNASIGMAR1ALDH1A1 | |
| SCHEMBL10721919 | 1.00 | EPHX1 (0.33) | EPHX1HTTLMNASIGMAR1ALDH1A1 | |
| SCHEMBL10721961 | 1.00 | EPHX1 (0.33) | EPHX1HTTLMNASIGMAR1ALDH1A1 | |
| SCHEMBL7020479 | 0.98 | HTT (0.34) | EPHX1HTTLMNA | |
| SCHEMBL10368168 | 0.98 | HTT (0.34) | EPHX1HTTLMNA | |
| SCHEMBL13316373 | 0.93 | HTT (0.34) | HTTLMNA | |
| SCHEMBL13349565 | 0.93 | HTT (0.34) | HTTLMNA | |
| SCHEMBL10722762 | 0.91 | HTT (0.35) | HTT | |
| SCHEMBL24629315 | 0.89 | HTT (0.39) | EPHX1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144720-A1 | INHIBITORS OF HUMAN TUMOR-EXPRESSED CCXCKR2 | CHEMOCENTRYX, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| EP-1454617-B1 | HAIR BLEACH AND DYE COMPOSITIONS | KAO CORP (JP) | 2010-05-05 | — | — | EP | disclosed |
| EP-1454617-B1 | HAIR BLEACH AND DYE COMPOSITIONS | KAO CORP (JP) | 2010-05-05 | — | — | EP | disclosed |
| US-7649011-B2 | Active against cancer proliferation, growth, and metastasis; such as 3,4,5-trimethoxy-n-(2-methyl-3-phenyl-allyl)-n-[2-(1-methyl-pyrrolidin-2-yl)-thyl]-benzamide; side effect reduction | CHEMOCENTRYX, INC. (US) | 2010-01-19 | — | — | US | disclosed |
| US-7649011-B2 | Active against cancer proliferation, growth, and metastasis; such as 3,4,5-trimethoxy-n-(2-methyl-3-phenyl-allyl)-n-[2-(1-methyl-pyrrolidin-2-yl)-thyl]-benzamide; side effect reduction | CHEMOCENTRYX, INC. (US) | 2010-01-19 | — | — | US | disclosed |
| US-7211116-B2 | Hair dye composition | KAO CORPORATION (JP) | 2007-05-01 | — | — | US | disclosed |
| US-7211116-B2 | Hair dye composition | KAO CORPORATION (JP) | 2007-05-01 | — | — | US | disclosed |
| CN-1691933-A | Hair dye composition | KAO CORP (JP) | 2005-11-02 | — | — | CN | disclosed |
| EP-1454617-A1 | HAIR DYE COMPOSITION | Kao Corporation (JP) | 2004-09-08 | — | — | EP | disclosed |
| US-4673686-A | CNS MODIFIERS, ANTI-APOMORPHINE ANTIENETIC ACITIVTY/ | SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLE DE L'ILE DE FRANCE (FR) | 1987-06-16 | — | — | US | disclosed |
| US-4041032-A | ANTIEMATICS, GASTRIC MOTILITY STIMULANTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JA) | 1977-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144720-A1 | INHIBITORS OF HUMAN TUMOR-EXPRESSED CCXCKR2 | CCL2, CCR2, CXCR2 | EPHX1 1656/4885HTT 3662/4885LMNA 4709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.