Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.64 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.64 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.44 |
| ▸ | BHMT | Q93088 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 8/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.43 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.43 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | ENPEP | Q07075 | 3/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL27647865 | 1.00 | PTGS1 (0.64) | PTGS1SLC7A11SLC7A5SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL28776970 | 0.92 | PTGS1 (0.76) | PTGS1SLC7A11SLC7A5SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL409120 | 0.92 | PTGS1 (0.76) | PTGS1SLC7A11SLC7A5SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL28090265 | 0.92 | PTGS1 (0.76) | PTGS1SLC7A11SLC7A5SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL409121 | 0.92 | PTGS1 (0.76) | PTGS1SLC7A11SLC7A5SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL23454434 | 0.89 | SLC7A5 (0.58) | PTGS1SLC7A11SLC7A5SLC1A3SLC1A2 | |
| Cysteine SCHEMBL14485654 | 0.89 | PTGS1 (0.80) | PTGS1SLC7A11SLC7A5SLC1A3SLC1A2 | |
| Cysteine SCHEMBL1675940 | 0.89 | PTGS1 (0.80) | PTGS1SLC7A11SLC7A5SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL939864 | 0.89 | SLC7A5 (0.58) | PTGS1SLC7A11SLC7A5SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL22092469 | 0.89 | SLC7A5 (0.58) | PTGS1SLC7A11SLC7A5SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1367121-B1 | Process for immobilizing polypeptides via the carboxyl group of the C-terminus | NAT INST OF ADVANCED IND SCIEN (JP) | 2010-05-19 | — | — | EP | disclosed |
| US-20090011958-A1 | PROCESS FOR IMMOBILIZING ORIENTATION-CONTROLLED PROTEIN AND PROCESS FOR ARRAYING AND IMMOBILIZING PROTEIN USING THE SAME | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE & TECHNOLOGY | 2009-01-08 | — | — | US | disclosed |
| US-20040014242-A1 | Process for immobilizing orientation-controlled protein and process for arraying and immobilizing protein using the same | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2004-01-22 | — | — | US | disclosed |
| EP-1367121-A2 | Process for immobilizing polypeptides via the carboxyl group of the C-terminus | National Institute of Advanced Industrial Science and Technology (JP) | 2003-12-03 | — | — | EP | disclosed |