Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.76 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.76 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.44 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL28776970 | 1.00 | PTGS1 (0.76) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Aspartic Acid SCHEMBL409120 | 1.00 | PTGS1 (0.76) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Aspartic Acid SCHEMBL409121 | 1.00 | PTGS1 (0.76) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Aspartic Acid SCHEMBL8628354 | 0.94 | PTGS1 (0.67) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Aspartic Acid SCHEMBL27647865 | 0.92 | PTGS1 (0.64) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Aspartic Acid SCHEMBL3247000 | 0.92 | PTGS1 (0.64) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Glutamic Acid SCHEMBL2999431 | 0.88 | GRM8 (0.67) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Aspartic Acid SCHEMBL7706079 | 0.87 | PTGS1 (0.55) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Cysteine SCHEMBL1868335 | 0.87 | PTGS1 (1.00) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Cysteine SCHEMBL5705430 | 0.87 | PTGS1 (1.00) | PTGS1SLC7A11GRIK1GRIK2GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103613669-B | Polypeptide for inhibiting cell proliferation and inducing apoptosis, preparation method and application thereof | 华中科技大学同济医学院附属同济医院 | 2016-08-17 | — | — | CN | disclosed |