Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24578032 | 0.83 | MAPT (0.42) | DYRK1BMAPTDAOKDM4EMEN1 | |
| SCHEMBL2333545 | 0.80 | MAPT (0.65) | KDRCSNK2A2CSNK2BCSNK2A1LIMK1 | |
| SCHEMBL4211782 | 0.78 | KDR (0.43) | KDRCSNK2A2CSNK2BCSNK2A1LIMK1 | |
| SCHEMBL3210679 | 0.78 | CISD2 (0.47) | KDRCSNK2A2CSNK2BCSNK2A1MAPT | |
| SCHEMBL1630492 | 0.77 | KDR (0.42) | KDRCSNK2A2CSNK2BCSNK2A1LIMK1 | |
| SCHEMBL6610392 | 0.70 | IKBKB (0.50) | KDRCSNK2A2CSNK2BCSNK2A1LIMK1 | |
| SCHEMBL6628482 | 0.69 | SMN1; SMN2 (0.46) | MAPTMEN1ALDH1A1KMT2AALOX15 | |
| SCHEMBL27398463 | 0.68 | F2 (0.47) | KDRCSNK2A2CSNK2BCSNK2A1LIMK1 | |
| SCHEMBL19437933 | 0.68 | KDR (0.42) | KDRCSNK2A2CSNK2BCSNK2A1LIMK1 | |
| SCHEMBL5156569 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |
| WO-2010001126-A1 | THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-01-07 | — | — | WO | disclosed |