Sugi Predict

Sugi Predict / Compounds / SCHEMBL3247333

SCHEMBL3247333

SCHEMBL3247333

COc1ccc(S(=O)(=O)N(CCNS(C)(=O)=O)c2ccc(Cl)cc2Cc2c(F)cccc2F)cc1OC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PKM P14618 3/20 0.46
▸ HCRTR2 O43614 2/20 0.42
▸ HCRTR1 O43613 1/20 0.42
▸ MAPT P10636 3/20 0.40
▸ TP53 P04637 2/20 0.40
▸ MCOLN3 Q8TDD5 3/20 0.39
▸ POLB P06746 2/20 0.39
▸ ALDH1A1 P00352 4/20 0.38
▸ TSHR P16473 2/20 0.38
▸ CYP1A2 P05177 1/20 0.38
▸ CYP3A4 P08684 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ NPSR1 Q6W5P4 2/20 0.38
▸ LMNA P02545 3/20 0.38
▸ HTT P42858 1/20 0.38
▸ MAPK1 P28482 1/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ PTGER1 P34995 1/20 0.37
▸ OXTR P30559 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4870970 0.92 PKM (0.48) PKMHCRTR2HCRTR1MAPTTP53
SCHEMBL3243770 0.89 PKM (0.47) PKMHCRTR2HCRTR1MAPTTP53
SCHEMBL3246448 0.89 PKM (0.46) PKMHCRTR2HCRTR1MAPTTP53
SCHEMBL3255886 0.88 PKM (0.48) PKMHCRTR2HCRTR1MAPTTP53
SCHEMBL3255521 0.88 PKM (0.48) PKMHCRTR2HCRTR1MAPTTP53
SCHEMBL3247054 0.88 PKM (0.49) PKMHCRTR2HCRTR1MAPTTP53
SCHEMBL3250401 0.88 PKM (0.49) PKMHCRTR2HCRTR1MAPTTP53
SCHEMBL4871023 0.88 PKM (0.52) PKMHCRTR2HCRTR1MAPTTP53
SCHEMBL3252995 0.88 PKM (0.47) PKMHCRTR2HCRTR1MAPTTP53
SCHEMBL3251964 0.88 PKM (0.49) PKMHCRTR2HCRTR1MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1776347-B1 SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION SANOFI AVENTIS (FR) 2010-05-26 — — EP disclosed
US-7396958-B2 Sulphonamide derivatives, their preparation and their therapeutic application SANOFI AVENTIS (FR) 2008-07-08 — — US disclosed
US-7396958-B2 Sulphonamide derivatives, their preparation and their therapeutic application SANOFI AVENTIS (FR) 2008-07-08 — — US disclosed
US-7396958-B2 Sulphonamide derivatives, their preparation and their therapeutic application SANOFI AVENTIS (FR) 2008-07-08 — — US disclosed
US-20070185136-A1 SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION SANOFI-AVENTIS (FR) 2007-08-09 — — US disclosed
US-20070185136-A1 SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION SANOFI-AVENTIS (FR) 2007-08-09 — — US disclosed
US-20070185136-A1 SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION SANOFI-AVENTIS (FR) 2007-08-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070185136-A1 SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION HCRTR2, GIPR, SSTR2 PKM 2524/4885HCRTR2 1/4885HCRTR1 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.