Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.53 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.51 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12313384 | 0.83 | HPGD (0.97) | HPGDALDH1A1POLBHRH3YEATS4 | |
| SCHEMBL11919033 | 0.81 | HPGD (1.00) | HPGDALDH1A1POLBHRH3YEATS4 | |
| SCHEMBL3240583 | 0.79 | HPGD (0.60) | HPGDALDH1A1POLBHRH3YEATS4 | |
| SCHEMBL8588589 | 0.76 | HRH3 (0.68) | HPGDALDH1A1POLBHRH3L3MBTL1 | |
| SCHEMBL24188536 | 0.75 | ALDH1A1 (0.67) | HPGDALDH1A1POLBHRH3YEATS4 | |
| SCHEMBL13155877 | 0.73 | HPGD (0.62) | HPGDALDH1A1POLBHRH3YEATS4 | |
| SCHEMBL3196789 | 0.73 | HPGD (0.96) | HPGDALDH1A1POLBYEATS4L3MBTL3 | |
| SCHEMBL20460413 | 0.73 | HPGD (0.96) | HPGDALDH1A1POLBYEATS4L3MBTL3 | |
| SCHEMBL3254670 | 0.73 | HPGD (0.62) | HPGDALDH1A1POLBHRH3YEATS4 | |
| SCHEMBL2637597 | 0.73 | HPGD (0.66) | HPGDALDH1A1POLBYEATS4L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2182809-A1 | THERAPEUTIC ISOXAZOLE COMPOUNDS | Helicon Therapeutics, Inc. (US) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009029632-A1 | THERAPEUTIC ISOXAZOLE COMPOUNDS | HELICON THERAPEUTICS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |