Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241960 | 0.88 | KDM4E (0.39) | PARGKDM4EHSD17B10MAPTHPGD | |
| SCHEMBL4717186 | 0.86 | PARG (0.41) | PARGKDM4EHTTHSD17B10MAPT | |
| SCHEMBL4161656 | 0.86 | PARG (0.39) | PARGKDM4EHSD17B10HPGDCYP2C19 | |
| SCHEMBL3243012 | 0.84 | PARG (0.56) | PARGKDM4EHTTHSD17B10MAPT | |
| SCHEMBL3242536 | 0.82 | TDP1 (0.53) | PARGKDM4EMAPTPOLBBACE1 | |
| SCHEMBL3251568 | 0.82 | PARG (0.48) | PARGKDM4EHTTHSD17B10MAPT | |
| SCHEMBL3252195 | 0.82 | KDM4E (0.39) | PARGKDM4EHTTHSD17B10MAPT | |
| SCHEMBL3248538 | 0.82 | TDP1 (0.54) | PARGKDM4EMAPTPOLBMEN1 | |
| SCHEMBL3249968 | 0.82 | TDP1 (0.54) | PARGKDM4EMAPTPOLBMEN1 | |
| SCHEMBL3247352 | 0.81 | KDM4E (0.40) | PARGKDM4EHTTHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |