Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.75 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.55 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.55 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243302 | 0.87 | ROCK2 (0.75) | ROCK2ROCK1CDC42BPACYP2C9MYLK4 | |
| SCHEMBL3241199 | 0.87 | ROCK2 (0.75) | ROCK2ROCK1CDC42BPACYP2C9MYLK4 | |
| SCHEMBL3248274 | 0.86 | ROCK2 (1.00) | ROCK2ROCK1MGLLMYLK4 | |
| SCHEMBL3246005 | 0.85 | ROCK2 (0.72) | ROCK2ROCK1CDC42BPACYP2C9 | |
| SCHEMBL3240681 | 0.82 | ROCK2 (1.00) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL3114815 | 0.79 | ROCK2 (0.78) | ROCK2ROCK1MYLK4 | |
| SCHEMBL3251290 | 0.77 | ROCK2 (0.74) | ROCK2ROCK1CDC42BPACYP2C9 | |
| SCHEMBL3245074 | 0.77 | ROCK2 (0.78) | ROCK2ROCK1CDC42BPACYP2C9 | |
| SCHEMBL21768565 | 0.77 | ROCK2 (0.63) | ROCK2ROCK1CDC42BPACYP2C9 | |
| SCHEMBL3251821 | 0.77 | ROCK2 (1.00) | ROCK2ROCK1MGLLMYLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |