Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.64 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.64 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13391213 | 0.90 | ROCK2 (0.71) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL3252352 | 0.86 | ROCK2 (0.64) | ROCK2ROCK1CDC42BPAAKT1 | |
| SCHEMBL13391093 | 0.86 | ROCK2 (0.73) | ROCK2ROCK1CDC42BPAAKT1 | |
| SCHEMBL3252347 | 0.85 | ROCK2 (0.54) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL15995994 | 0.84 | ROCK2 (0.61) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL15995997 | 0.84 | ROCK2 (0.61) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL13819405 | 0.81 | ROCK2 (0.59) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL1253693 | 0.80 | ROCK2 (0.65) | ROCK2ROCK1CDC42BPAAKT1 | |
| SCHEMBL12915044 | 0.80 | ROCK2 (0.62) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL3239562 | 0.80 | ROCK2 (0.59) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |