Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14197242 | 0.87 | ALDH1A1 (0.56) | ALDH1A1KMT2ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL3249503 | 0.86 | KMT2A (0.75) | ALDH1A1KMT2ASMN1; SMN2LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL4830876 | 0.85 | ALDH1A1 (0.55) | ALDH1A1KMT2ASMN1; SMN2LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL23610493 | 0.85 | KMT2A (0.73) | ALDH1A1KMT2ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL21764931 | 0.84 | ALDH1A1 (0.53) | ALDH1A1KMT2ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL3130369 | 0.84 | ALDH1A1 (0.56) | ALDH1A1KMT2ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL13043452 | 0.83 | KMT2A (0.57) | ALDH1A1KMT2ASMN1; SMN2LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL21753322 | 0.83 | ALDH1A1 (0.52) | ALDH1A1KMT2ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL21765255 | 0.82 | ALDH1A1 (0.51) | ALDH1A1KMT2ASMN1; SMN2LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL3394599 | 0.82 | KMT2A (0.56) | ALDH1A1KMT2ASMN1; SMN2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |