Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 13/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13928213 | 0.89 | JAK2 (0.38) | PIM1PIM3PIM2 | |
| SCHEMBL3251264 | 0.89 | PDPK1 (0.43) | PIM1ENPP2PRKAG1PRKAA1PRKAB1 | |
| Formic Acid SCHEMBL3249581 | 0.86 | JAK3 (0.36) | PIM1PIM3PIM2 | |
| SCHEMBL4174413 | 0.85 | PIM1 (0.41) | PIM1PIM3PIM2TLR9TLR8 | |
| Formic Acid SCHEMBL4159384 | 0.83 | PIM1 (0.36) | PIM1PIM3PIM2TLR9TLR8 | |
| SCHEMBL3249380 | 0.83 | CAMKK2 (0.46) | PIM1PIM3PIM2TET2TET1 | |
| SCHEMBL4159388 | 0.81 | PIM1 (0.36) | PIM1PIM3PIM2 | |
| SCHEMBL3245619 | 0.81 | AURKA (0.47) | PIM1PIM3PIM2TET2TET1 | |
| SCHEMBL3245517 | 0.80 | PDPK1 (0.46) | PIM1PIM2ENPP2TET2TET1 | |
| SCHEMBL3247681 | 0.79 | JAK2 (0.42) | PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |