Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3251041 | 0.90 | MAPT (0.50) | MEN1KMT2ARAB9ABRD4MAPT | |
| SCHEMBL3246043 | 0.90 | BRD4 (0.48) | MEN1KMT2ARAB9APKMBRD4 | |
| SCHEMBL3249236 | 0.89 | BRD4 (0.60) | BRD4MAPTHTR6 | |
| SCHEMBL3245598 | 0.88 | BRD4 (0.48) | MEN1KMT2ARAB9ABRD4HTR6 | |
| SCHEMBL3248975 | 0.88 | POLB (0.49) | MEN1KMT2APKMBRD4GAA | |
| SCHEMBL3248780 | 0.88 | BRD4 (0.58) | PKMBRD4MAPTGAAHTR6 | |
| SCHEMBL3249171 | 0.88 | CHEK1 (0.51) | KMT2ABRD4LMNASMN1; SMN2ALOX15 | |
| SCHEMBL3242688 | 0.88 | BRD4 (0.60) | MEN1KMT2ABRD4MAPTHTR6 | |
| SCHEMBL3255249 | 0.88 | BRD4 (0.60) | MEN1KMT2APKMBRD4MAPT | |
| SCHEMBL3254000 | 0.87 | LMNA (0.53) | MEN1KMT2ARAB9APKMBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |