Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.34 |
| ▸ | PDE4A | P27815 | 8/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.34 |
| ▸ | PDE5A | O76074 | 3/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249447 | 0.94 | PDE4B (0.41) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL3126147 | 0.81 | PDE4B (0.39) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL3201072 | 0.80 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3193323 | 0.80 | PDE4B (0.41) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3118118 | 0.79 | PDE4B (0.56) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL3202579 | 0.79 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL3131319 | 0.78 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3211522 | 0.78 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3209523 | 0.77 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3215150 | 0.77 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |