Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azd-4017. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 known ✓ | P28845 | 16/20 | 0.88 |
| ▸ | IDH1 | O75874 | 4/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azd-4017 SCHEMBL2006589 | 0.94 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| Azd-4017 SCHEMBL1967884 | 0.94 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| Azd-4017 SCHEMBL1967349 | 0.94 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| Azd-4017 SCHEMBL3401359 | 0.93 | HSD11B1 (0.75) | HSD11B1IDH1 | |
| SCHEMBL1972472 | 0.91 | HSD11B1 (0.77) | HSD11B1IDH1 | |
| SCHEMBL1969175 | 0.90 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| SCHEMBL1971049 | 0.90 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| SCHEMBL1969178 | 0.90 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| SCHEMBL12571260 | 0.87 | HSD11B1 (0.87) | HSD11B1IDH1 | |
| SCHEMBL2005939 | 0.87 | HSD11B1 (0.87) | HSD11B1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086939-B1 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2010-07-28 | — | — | EP | claimed |