Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.74 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.74 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247662 | 0.96 | ROCK2 (0.75) | ROCK2ROCK1CDC42BPACYP3A4CYP2D6 | |
| SCHEMBL20511546 | 0.95 | ROCK2 (0.71) | ROCK2ROCK1CDC42BPACYP3A4CYP2D6 | |
| SCHEMBL3241720 | 0.94 | ROCK2 (0.70) | ROCK2ROCK1CDC42BPACYP3A4CYP2D6 | |
| SCHEMBL3130135 | 0.93 | ROCK2 (0.80) | ROCK2ROCK1CDC42BPACYP3A4CYP2D6 | |
| SCHEMBL3121595 | 0.93 | ROCK2 (0.80) | ROCK2ROCK1CDC42BPACYP3A4CYP2D6 | |
| SCHEMBL3242776 | 0.91 | ROCK2 (0.77) | ROCK2ROCK1CDC42BPACYP3A4CYP2D6 | |
| SCHEMBL3242868 | 0.90 | ROCK2 (0.82) | ROCK2ROCK1CDC42BPACYP3A4CYP2D6 | |
| SCHEMBL3126880 | 0.89 | ROCK2 (0.80) | ROCK2ROCK1CDC42BPACYP3A4CYP2D6 | |
| SCHEMBL3247361 | 0.89 | ROCK2 (0.72) | ROCK2ROCK1CDC42BPACYP3A4CYP2D6 | |
| SCHEMBL3239470 | 0.89 | ROCK2 (0.80) | ROCK2ROCK1CDC42BPACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |