Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240544 | 0.85 | ESR1 (0.54) | ESR1ABCG2ABCB1KDM4EPGR | |
| SCHEMBL16373146 | 0.79 | SIGMAR1 (0.71) | ESR1ABCG2ABCB1KDM4EPGR | |
| SCHEMBL11479762 | 0.78 | ESR1 (0.54) | ESR1ABCG2ABCB1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL11472041 | 0.77 | ESR1 (0.53) | ESR1ABCG2ABCB1KDM4EMEN1 | |
| SCHEMBL11176271 | 0.74 | KDM4E (0.48) | ESR1ABCG2ABCB1KDM4EMEN1 | |
| SCHEMBL11481659 | 0.74 | KDM4E (0.48) | ESR1ABCG2ABCB1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL11470335 | 0.74 | MEN1 (0.53) | ESR1ABCG2ABCB1KDM4EMEN1 | |
| SCHEMBL11178936 | 0.74 | KDM4E (0.47) | ESR1ABCG2ABCB1KDM4EMEN1 | |
| SCHEMBL8386930 | 0.73 | ESR1 (0.68) | ESR1ABCG2ABCB1PGRLMNA | |
| SCHEMBL11454881 | 0.73 | MAPKAPK2 (0.50) | ESR1ABCG2ABCB1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102204-B1 | NEW AMINOPYRROLO[1,2- A]INDOLE ET AMINOPYRIDAZINO[1,6-A]INDOLE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SERVIER LAB (FR) | 2010-05-05 | — | — | EP | disclosed |