Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246215 | 1.00 | MAPT (0.35) | MAPTTP53LMNAKDM4EKMT2A | |
| SCHEMBL13928180 | 0.90 | MAPT (0.33) | MAPTTP53LMNAKDM4EHSD17B10 | |
| SCHEMBL4153570 | 0.87 | SCN9A (0.32) | MAPTTP53LMNAKDM4ECA2 | |
| SCHEMBL4714851 | 0.86 | CA2 (0.35) | TP53KDM4EHSD17B10CA1CA2 | |
| SCHEMBL3250201 | 0.85 | MAPT (0.31) | MAPTTP53LMNAKDM4EHSD17B10 | |
| SCHEMBL3249112 | 0.84 | MAPT (0.38) | MAPTTP53LMNAKDM4EKMT2A | |
| SCHEMBL3251302 | 0.84 | MAPT (0.38) | MAPTTP53LMNAKDM4EKMT2A | |
| SCHEMBL3249109 | 0.84 | MAPT (0.38) | MAPTTP53LMNAKDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL3243095 | 0.84 | MAPT (0.38) | MAPTTP53LMNAKDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL3243100 | 0.84 | MAPT (0.38) | MAPTTP53LMNAKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |