Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 17/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.79 |
| ▸ | HPGD | P15428 | 7/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 5/20 | 0.55 |
| ▸ | CASP1 | P29466 | 5/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6461607 | 0.87 | KDM4E (0.73) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL3003468 | 0.86 | KDM4E (0.79) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL3007241 | 0.84 | KDM4E (0.60) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL12135860 | 0.83 | KDM4E (0.59) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL3244269 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL3008977 | 0.79 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL12135700 | 0.78 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL2999605 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL12135704 | 0.77 | KDM4E (0.63) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL12135921 | 0.76 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |