Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | CASP1 | P29466 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 5/20 | 0.51 |
| ▸ | CASP7 | P55210 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003468 | 0.83 | KDM4E (0.79) | KDM4EALDH1A1HSD17B10HPGDCASP1 | |
| SCHEMBL3250423 | 0.83 | KDM4E (0.79) | KDM4EALDH1A1HSD17B10HPGDCASP1 | |
| SCHEMBL3008977 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1HSD17B10HPGDCASP1 | |
| SCHEMBL13521836 | 0.73 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10HPGDCASP1 | |
| SCHEMBL13096488 | 0.73 | KDM4E (0.69) | KDM4EALDH1A1HSD17B10HPGDCASP1 | |
| SCHEMBL3005577 | 0.71 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10HPGDCASP1 | |
| SCHEMBL6461607 | 0.70 | KDM4E (0.73) | KDM4EALDH1A1HSD17B10HPGDCASP1 | |
| SCHEMBL5333713 | 0.69 | KDM4E (0.65) | KDM4EALDH1A1HSD17B10HPGDCASP1 | |
| SCHEMBL5823841 | 0.69 | HTR1A (0.48) | KDM4EALDH1A1HSD17B10HPGDCASP1 | |
| SCHEMBL5816717 | 0.68 | HTR1A (0.60) | KDM4EALDH1A1HSD17B10HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |