SCHEMBL3250464

SCHEMBL3250464

O=C=Nc1ccccc1-c1ccc2c(c1N=C=O)CC2

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.37
AKR1B1 P15121 1/20 0.32
GABRA1 P14867 1/20 0.32
GABRB2 P47870 1/20 0.32
CES1 P23141 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9183951 0.78 CYP3A4 (0.50) CYP3A4GABRA1GABRB2
SCHEMBL9653139 0.78 CYP3A4 (0.36) CYP3A4GABRA1GABRB2
SCHEMBL112824 0.77 CYP3A4 (0.56) CYP3A4GABRA1GABRB2CES1
SCHEMBL29099802 0.75 CYP3A4 (0.54) CYP3A4GABRA1GABRB2CES1
SCHEMBL9710104 0.74 CYP3A4 (0.50) CYP3A4GABRA1GABRB2CES1
SCHEMBL6318550 0.73 CYP3A4 (0.38) CYP3A4GABRA1GABRB2
SCHEMBL3213502 0.73 CYP3A4 (0.50) CYP3A4GABRA1GABRB2
SCHEMBL393344 0.72 CYP3A4 (0.44) CYP3A4GABRA1GABRB2CES1
SCHEMBL6866459 0.72 CYP3A4 (0.53) CYP3A4GABRA1GABRB2
SCHEMBL6676775 0.72 CYP3A4 (0.37) CYP3A4GABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1991600-B1 RESORCINOL-BLOCKED ISOCYANATE COMPOSITIONS AND THEIR APPLICATIONS INDSPEC CHEMICAL CORP (US) 2016-12-21 EP disclosed
EP-1890878-B1 COMPOSITE ELEMENTS, COMPRISING NONWOVEN THERMOPLASTIC POLYURETHANE FABRIC BASF SE (DE) 2013-09-18 EP disclosed
EP-2121312-B1 LAMINATE CONTAINING FILM AND NONWOVEN MATERIAL BASED ON THERMOPLASTIC POLYURETHANE BASF SE (DE) 2010-05-19 EP disclosed
US-7705088-B2 blocked isocyanate with hydroxy is derived from the reaction between a resorcinol compound and at least two different isocyanate compounds; improved adhesion of reinforcing materials to rubbers; used in fabric dipping formulations INDSPEC CHEMICAL CORPORATION (US) 2010-04-27 US disclosed
US-7700687-B2 Resorcinol resin-blocked isocyanates and their applications INDSPEC CHEMICAL CORPORATION (US) 2010-04-20 US disclosed
EP-1991600-A1 RESORCINOL-BLOCKED ISOCYANATE COMPOSITIONS AND THEIR APPLICATIONS INDSPEC CHEMICAL CORPORATION (US) 2008-11-19 EP disclosed
EP-1971625-A2 RESORCINOL RESIN-BLOCKED ISOCYANATES AND THEIR APPLICATIONS INDSPEC CHEMICAL CORPORATION (US) 2008-09-24 EP disclosed
WO-2007106186-A2 RESORCINOL RESIN-BLOCKED ISOCYANATES AND THEIR APPLICATIONS INDSPEC CHEMICAL CORPORATION (US) 2007-09-20 WO disclosed
US-20070219306-A1 Resorcinol Resin-Blocked Isocyanates and Their Applications INDSPEC CHEMICAL CORPORATION (US) 2007-09-20 US disclosed
WO-2007100399-A1 RESORCINOL-BLOCKED ISOCYANATE COMPOSITIONS AND THEIR APPLICATIONS INDSPEC CHEMICAL CORPORATION (US) 2007-09-07 WO disclosed
US-20070205393-A1 Resorcinol-Blocked Isocyanate Compositions and Their Applications INDSPEC CHEMICAL CORPORATION (US) 2007-09-06 US disclosed