SCHEMBL325297

SCHEMBL325297

N#Cc1cc(C2=NCC(c3cc(F)cc(C(F)(F)F)c3)(C(F)(F)F)C2)ccc1-n1cncn1

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
KDM4E B2RXH2 2/20 0.32
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.32
HSD17B10 Q99714 1/20 0.32
GAA P10253 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
NTRK1 P04629 1/20 0.30
ALOX5AP P20292 1/20 0.30
CYP11B1 P15538 1/20 0.30
CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL807501 0.88 ALOX5AP (0.31) ALOX5AP
SCHEMBL325242 0.88 HSD17B10 (0.37) ALDH1A1MAPTHPGDKDM4ETSHR
SCHEMBL326219 0.87 CNR2 (0.33) ALDH1A1KDM4EALOX5AP
SCHEMBL855560 0.86 ALOX5AP (0.33) ALOX5AP
SCHEMBL325427 0.85
SCHEMBL325579 0.84 KDM4E (0.34) ALDH1A1HPGDKDM4ETSHRMAPK1
SCHEMBL318922 0.79 CYP11B1 (0.36) ALOX5APCYP11B1CYP11B2
SCHEMBL12942933 0.75 KDM4E (0.32) ALDH1A1KDM4E
SCHEMBL807496 0.75 CNR2 (0.31) ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL4752991 0.74 ALDH1A1 (0.36) ALDH1A1MAPTHPGDKDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012004326-A1 PESTICIDAL PYRROLINE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-12 WO disclosed