SCHEMBL3253522

SCHEMBL3253522

O=C(O)N1CCC[C@H]1CNC1CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 16/20 0.47
DPP7 Q9UHL4 7/20 0.47
FAP Q12884 7/20 0.43
POLB P06746 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
DPP8 Q6V1X1 2/20 0.39
DPP9 Q86TI2 2/20 0.39
HRH3 Q9Y5N1 1/20 0.37
KDM4E B2RXH2 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
APP P05067 1/20 0.34
HTR1A P08908 1/20 0.34
ADRA2A P08913 1/20 0.34
DRD2 P14416 1/20 0.34
ADRA2B P18089 1/20 0.34
ADRA2C P18825 1/20 0.34
SLC6A2 P23975 1/20 0.34
HRH2 P25021 1/20 0.34
HTR1D P28221 1/20 0.34
HTR1B P28222 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14186210 0.84 DPP4 (0.46) DPP4DPP7FAPPOLBL3MBTL1
SCHEMBL13188860 0.80 L3MBTL1 (0.44) DPP4DPP7FAPPOLBL3MBTL1
SCHEMBL25184347 0.80 L3MBTL1 (0.44) DPP4DPP7FAPPOLBL3MBTL1
SCHEMBL14186213 0.79 DPP4 (0.48) DPP4DPP7FAPPOLBL3MBTL1
SCHEMBL24260140 0.79 DPP4 (0.42) DPP4DPP7FAPHRH3
SCHEMBL14186209 0.79 DPP4 (0.48) DPP4DPP7FAPPOLBL3MBTL1
SCHEMBL14569751 0.79 DPP4 (0.43) DPP4DPP7FAPPOLBL3MBTL1
SCHEMBL14215142 0.78 DPP4 (0.49) DPP4DPP7FAPPOLBL3MBTL1
SCHEMBL24260320 0.78 L3MBTL1 (0.44) DPP4DPP7FAPPOLBL3MBTL1
SCHEMBL24260364 0.77 DPP4 (0.43) DPP4DPP7FAPKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1899335-B1 PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS PF MEDICAMENT (FR) 2010-05-19 EP disclosed
EP-1899335-A1 PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS PIERRE FABRE MEDICAMENT (FR) 2008-03-19 EP disclosed
WO-2007003611-A1 PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS PIERRE FABRE MEDICAMENT (FR) 2007-01-11 WO disclosed