Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147533 | 0.93 | KCNH2 (0.60) | KCNH2KDM4EL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL1147941 | 0.87 | MAPT (0.51) | KCNH2KDM4EL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL1147940 | 0.87 | MAPT (0.51) | KCNH2KDM4EL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL1148133 | 0.85 | KDM4E (0.56) | KDM4EL3MBTL1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1147868 | 0.84 | KDM4E (0.49) | KCNH2KDM4EL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL3244126 | 0.81 | KCNH2 (0.49) | KCNH2KDM4EMAPTSMN1; SMN2MEN1 | |
| SCHEMBL1147192 | 0.81 | KCNH2 (0.54) | KCNH2KDM4EL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL1147454 | 0.74 | KCNH2 (0.68) | KCNH2KDM4EL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1148179 | 0.74 | KCNH2 (0.68) | KCNH2KDM4EL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1148100 | 0.74 | KCNH2 (0.68) | KCNH2KDM4EL3MBTL1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001478-B1 | CYCLOHEXYL OR PIPERIDINYL CARBOXAMIDE ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-06-02 | — | — | EP | claimed |