SCHEMBL325397

SCHEMBL325397

C=C(C=C(C)C)O[Si](C)(C)C(C)(C)C

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3341392 0.77
SCHEMBL15272637 0.76
SCHEMBL31579944 0.74
SCHEMBL2648793 0.74
SCHEMBL1898469 0.71
SCHEMBL1898470 0.71
SCHEMBL24022528 0.70
SCHEMBL14269405 0.70
SCHEMBL1724356 0.69 TDP1 (0.31)
SCHEMBL13453893 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3564233-B1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2023-05-03 EP disclosed
EP-4101849-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS Novartis AG (CH) 2022-12-14 EP disclosed
US-20220387428-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2022-12-08 US disclosed
US-11229648-B2 1,4-disubstituted pyridazine analogs thereof and methods for treating SMN-deficiency-related conditions NOVARTIS AG (CH) 2022-01-25 US disclosed
EP-2885288-B1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2021-10-06 EP disclosed
US-20200345732-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2020-11-05 US disclosed
US-10758533-B2 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions NOVARTIS AG (CH) 2020-09-01 US disclosed
EP-3212184-B1 SUBSTITUTED BENZOTETRAHYDROPYRANS AND THEIR USE ABBVIE OVERSEAS SARL (LU) 2020-04-01 EP disclosed
EP-3564233-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS Novartis AG (CH) 2019-11-06 EP disclosed
US-10195196-B2 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions NOVARTIS AG (CH) 2019-02-05 US disclosed
EP-2885288-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS Novartis AG (CH) 2015-06-24 EP disclosed
US-20140213570-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2014-07-31 US disclosed
US-8729263-B2 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions NOVARTIS AG (CH) 2014-05-20 US disclosed
US-20140051672-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2014-02-20 US disclosed
WO-2014028459-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2014-02-20 WO disclosed
EP-2590968-A1 CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS Novartis AG (CH) 2013-05-15 EP disclosed
US-20130109682-A1 CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS NOVARTIS AG (CH) 2013-05-02 US disclosed
US-20130109682-A1 CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS NOVARTIS AG (CH) 2013-05-02 US disclosed
US-20130109682-A1 CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS NOVARTIS AG (CH) 2013-05-02 US disclosed
WO-2012004217-A1 CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS NOVARTIS AG (CH) 2012-01-12 WO disclosed