Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.47 |
| ▸ | GPR6 | P46095 | 9/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252397 | 0.91 | GPR6 (0.45) | GPR119GPR6 | |
| SCHEMBL389780 | 0.89 | GPR119 (0.52) | GPR119GPR6ERBB2 | |
| SCHEMBL3252343 | 0.85 | ACACB (0.44) | ERBB2 | |
| SCHEMBL5821405 | 0.81 | GPR119 (0.48) | GPR119GPR6 | |
| SCHEMBL3257201 | 0.80 | GPR119 (0.41) | GPR119GPR6ERBB2 | |
| SCHEMBL390736 | 0.80 | GPR119 (0.54) | GPR119GPR6 | |
| SCHEMBL3257084 | 0.79 | GPR119 (0.55) | GPR119GPR6 | |
| SCHEMBL14475921 | 0.78 | GPR119 (0.46) | GPR119 | |
| SCHEMBL3252680 | 0.78 | GPR119 (0.39) | GPR119GPR6ERBB2 | |
| SCHEMBL3252644 | 0.78 | ACACB (0.39) | GPR119GPR6ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1911756-B9 | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto | ARENA PHARM INC (US) | 2010-05-26 | — | — | EP | claimed |
| EP-1911756-B1 | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto | ARENA PHARM INC (US) | 2009-10-21 | — | — | EP | claimed |
| EP-1732562-B1 | SUBSTITUTED PYRIDINYL AND PYRIMIDINYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2007-12-19 | — | — | EP | claimed |