Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3258450 | 0.93 | PRCP (0.32) | — | |
| SCHEMBL3258852 | 0.85 | TSHR (0.34) | RORCAURKA | |
| SCHEMBL3258385 | 0.80 | GAA (0.37) | HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL3254116 | 0.78 | RORC (0.33) | RORC | |
| SCHEMBL3256735 | 0.76 | RORC (0.33) | RORCAURKA | |
| SCHEMBL3257059 | 0.74 | AURKA (0.35) | RORCAURKAHDAC1 | |
| SCHEMBL3254433 | 0.74 | RORC (0.31) | RORC | |
| SCHEMBL3256633 | 0.73 | GAA (0.36) | — | |
| SCHEMBL3251075 | 0.73 | TP53 (0.35) | RORCAURKA | |
| SCHEMBL3256116 | 0.72 | RORC (0.31) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |