Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 5/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3257373 | 0.78 | HCAR2 (0.36) | KCNH2TAAR1CHRM2HRH1SIGMAR1 | |
| SCHEMBL28966782 | 0.73 | IGF1R (0.61) | IGF1RALOX15KCNH2HDAC3HDAC4 | |
| SCHEMBL1115439 | 0.73 | IGF1R (0.61) | IGF1RALOX15KCNH2HDAC3HDAC4 | |
| SCHEMBL10365734 | 0.71 | IGF1R (0.64) | IGF1RALOX15KCNH2HDAC3HDAC4 | |
| SCHEMBL16728131 | 0.66 | — | — | |
| SCHEMBL18050371 | 0.66 | TAAR1 (0.62) | IGF1RALOX15KCNH2HDAC3HDAC4 | |
| SCHEMBL16230233 | 0.66 | — | — | |
| SCHEMBL8723191 | 0.66 | MAOB (0.58) | IGF1RALOX15KCNH2HTR2ASIGMAR1 | |
| SCHEMBL12040532 | 0.66 | MAOB (0.58) | IGF1RALOX15KCNH2HTR2ASIGMAR1 | |
| SCHEMBL7562217 | 0.64 | KCNH2 (0.53) | IGF1RALOX15KCNH2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029601-B1 | PYRIDOPYRIMIDINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-06-02 | — | — | EP | disclosed |