Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | CASP7 | P55210 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2755206 | 0.79 | AURKA (0.46) | KDM4ERAB9ANPC1CASP1HSD17B10 | |
| SCHEMBL239290 | 0.78 | KDR (0.39) | KDM4ERAB9ANPC1KDRHSD17B10 | |
| SCHEMBL239305 | 0.75 | KDM4E (0.41) | KDM4ERAB9ANPC1KDRCASP1 | |
| SCHEMBL236760 | 0.72 | KDM4E (0.47) | KDM4ECASP1HSD17B10CASP7L3MBTL1 | |
| SCHEMBL238204 | 0.72 | CYP1A2 (0.38) | KDM4ECASP1HSD17B10CASP7L3MBTL1 | |
| SCHEMBL7691166 | 0.67 | KDM4E (0.53) | KDM4ERAB9ANPC1CASP1HSD17B10 | |
| SCHEMBL1901480 | 0.66 | RAB9A (1.00) | KDM4ERAB9ANPC1CASP1HSD17B10 | |
| SCHEMBL2630604 | 0.66 | RAB9A (0.74) | KDM4ERAB9ANPC1CASP1HSD17B10 | |
| SCHEMBL29820118 | 0.66 | RAB9A (1.00) | KDM4ERAB9ANPC1CASP1HSD17B10 | |
| SCHEMBL239135 | 0.65 | KDR (0.40) | KDRPDE3BPDE3ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406250-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2015-08-12 | — | — | EP | disclosed |
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CD, PIK3CA, PIK3R5 | KDM4E 2166/4885RAB9A 778/4885NPC1 1127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.