Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14046558 | 0.80 | CHRM2 (0.40) | CYP3A4ALDH1A1CA2TSHRTDP1 | |
| SCHEMBL3250012 | 0.77 | CYP3A4 (0.49) | CYP3A4ALDH1A1MMP9MMP8MMP14 | |
| SCHEMBL182476 | 0.74 | KDM4E (0.32) | ALDH1A1 | |
| SCHEMBL1835296 | 0.69 | CYP3A4 (0.74) | CYP3A4ALDH1A1MMP9MMP8MMP14 | |
| SCHEMBL15511468 | 0.69 | CYP3A4 (0.55) | CYP3A4ALDH1A1MMP9MMP8MMP14 | |
| SCHEMBL2721504 | 0.68 | MEN1 (0.37) | TSHRMAPK1 | |
| SCHEMBL11905467 | 0.67 | CYP3A4 (0.71) | CYP3A4ALDH1A1MMP9MMP8MMP14 | |
| SCHEMBL5469162 | 0.67 | CYP3A4 (0.78) | CYP3A4ALDH1A1MMP9MMP8MMP14 | |
| SCHEMBL2241603 | 0.67 | CYP3A4 (0.78) | CYP3A4ALDH1A1MMP9MMP8MMP14 | |
| SCHEMBL13007628 | 0.67 | CYP3A4 (0.71) | CYP3A4ALDH1A1MMP9MMP8MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799932-B2 | N-substituted 3,4-alkylenedioxypyrroles, ester substituted dihydroxypyrroles and methods for synthesis of these pyrroles | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-09-21 | — | — | US | disclosed |
| US-7799932-B2 | N-substituted 3,4-alkylenedioxypyrroles, ester substituted dihydroxypyrroles and methods for synthesis of these pyrroles | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-09-21 | — | — | US | disclosed |
| US-7799932-B2 | N-substituted 3,4-alkylenedioxypyrroles, ester substituted dihydroxypyrroles and methods for synthesis of these pyrroles | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-09-21 | — | — | US | disclosed |
| EP-1931630-B1 | N-SUBSTITUTED 3,4-ALKYLENEDIOXYPYRROLES, ESTER SUBSTITUTED DIHYDROXYPYRROLES AND METHODS FOR SYNTHESIS OF THESE PYRROLES | UNIV FLORIDA (US) | 2010-05-12 | — | — | EP | disclosed |
| EP-1931630-B1 | N-SUBSTITUTED 3,4-ALKYLENEDIOXYPYRROLES, ESTER SUBSTITUTED DIHYDROXYPYRROLES AND METHODS FOR SYNTHESIS OF THESE PYRROLES | UNIV FLORIDA (US) | 2010-05-12 | — | — | EP | disclosed |
| US-20090149661-A1 | N-Substituted 3,4-Alkylenedioxypyrroles, Ester Substituted Dihydroxypyrroles and Methods for Synthesis of These Pyrroles | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-06-11 | — | — | US | disclosed |
| US-20090149661-A1 | N-Substituted 3,4-Alkylenedioxypyrroles, Ester Substituted Dihydroxypyrroles and Methods for Synthesis of These Pyrroles | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-06-11 | — | — | US | disclosed |
| US-20090149661-A1 | N-Substituted 3,4-Alkylenedioxypyrroles, Ester Substituted Dihydroxypyrroles and Methods for Synthesis of These Pyrroles | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-06-11 | — | — | US | disclosed |
| WO-2007041724-A1 | N-SUBSTITUTED 3,4-ALKYLENEDIOXYPYRROLES, ESTER SUBSTITUTED DIHYDROXYPYRROLES AND METHODS FOR SYNTHESIS OF THESE PYRROLES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149661-A1 | N-Substituted 3,4-Alkylenedioxypyrroles, Ester Substituted Dihydroxypyrroles and Methods for Synthesis of These Pyrroles | PAH, DDT, DHPS | CYP3A4 17/4885ALDH1A1 430/4885MMP9 4781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.