Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.71 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.49 |
| ▸ | EDNRB | P24530 | 2/20 | 0.35 |
| ▸ | EDNRA | P25101 | 2/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254706 | 0.89 | HSD11B1 (0.86) | HSD11B1HSD17B1HSD17B2EDNRBEDNRA | |
| SCHEMBL3250977 | 0.83 | HSD11B1 (0.86) | HSD11B1HSD17B1HSD17B2EDNRBEDNRA | |
| SCHEMBL3255788 | 0.82 | HSD11B1 (0.84) | HSD11B1HSD17B1HSD17B2EDNRBEDNRA | |
| SCHEMBL3255959 | 0.82 | HSD11B1 (0.83) | HSD11B1HSD17B1HSD17B2EDNRBEDNRA | |
| SCHEMBL3253535 | 0.82 | HSD11B1 (0.83) | HSD11B1HSD17B1HSD17B2EDNRBEDNRA | |
| SCHEMBL3254118 | 0.81 | HSD11B1 (0.79) | HSD11B1HSD17B1HSD17B2EDNRBEDNRA | |
| SCHEMBL3256129 | 0.81 | HSD11B1 (0.82) | HSD11B1HSD17B1HSD17B2EDNRBEDNRA | |
| SCHEMBL3255987 | 0.78 | HSD11B1 (0.71) | HSD11B1HSD17B1HSD17B2EDNRBEDNRA | |
| SCHEMBL6625837 | 0.76 | HSD11B1 (0.67) | HSD11B1HSD17B1HSD17B2 | |
| SCHEMBL3253110 | 0.76 | HSD11B1 (0.69) | HSD11B1HSD17B1HSD17B2EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2010-05-26 | — | — | EP | claimed |