Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.35 |
| ▸ | HPGD | P15428 | 7/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4159975 | 0.87 | KDM4E (0.33) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3255165 | 0.86 | KDM4E (0.35) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3255219 | 0.85 | MAPT (0.35) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3242961 | 0.84 | MAPT (0.39) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3246215 | 0.82 | MAPT (0.35) | KDM4EMEN1KMT2AADRB2RECQL | |
| Butyric Acid SCHEMBL4159977 | 0.82 | KDM4E (0.35) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3246221 | 0.82 | MAPT (0.35) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3250002 | 0.82 | MAPT (0.35) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL4153193 | 0.81 | GAA (0.39) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3248316 | 0.80 | MAPT (0.38) | KDM4EMEN1KMT2AADRB2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |