Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | CRHBP | P24387 | 2/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216937 | 0.92 | PDE5A (0.53) | MEN1KMT2AHPGDPDE4BALDH1A1 | |
| SCHEMBL11160675 | 0.88 | MEN1 (0.51) | MEN1KMT2AHPGDPDE4BALDH1A1 | |
| SCHEMBL11162717 | 0.88 | ALDH1A1 (0.51) | MEN1KMT2AHPGDPDE4BALDH1A1 | |
| SCHEMBL11162923 | 0.85 | MEN1 (0.48) | MEN1KMT2AHPGDPDE4BALDH1A1 | |
| SCHEMBL5914393 | 0.83 | MEN1 (0.55) | MEN1KMT2AHPGDPDE4BALDH1A1 | |
| SCHEMBL3256027 | 0.83 | MEN1 (0.55) | MEN1KMT2AHPGDPDE4BALDH1A1 | |
| SCHEMBL11166045 | 0.82 | PDE4B (0.62) | MEN1KMT2AHPGDPDE4BALDH1A1 | |
| SCHEMBL2902262 | 0.81 | PDE5A (0.58) | MEN1KMT2AALDH1A1LMNATDP1 | |
| SCHEMBL11281579 | 0.81 | PDE4B (0.53) | MEN1KMT2AHPGDPDE4BALDH1A1 | |
| SCHEMBL11883425 | 0.79 | PDE4B (0.43) | MEN1KMT2AHPGDPDE4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474147-B1 | PYRIMIDINE-BASED COMPOUNDS USEFUL AS GSK-3 INHIBITORS | VERTEX PHARMA (US) | 2010-05-05 | — | — | EP | disclosed |