Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 7/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255653 | 1.00 | PARG (0.38) | PARGTDP1KDM4EHTTPOLB | |
| SCHEMBL4157940 | 0.87 | PARG (0.34) | PARGTDP1BRAFHRH1CCR3 | |
| SCHEMBL4717788 | 0.86 | PARG (0.42) | PARGTDP1KDM4EBRAFHRH1 | |
| SCHEMBL4159322 | 0.86 | CCR8 (0.43) | PARGTDP1KDM4EPOLBHSD17B10 | |
| Butyric Acid SCHEMBL4157941 | 0.83 | PARG (0.38) | PARGTDP1KDM4EMEN1KMT2A | |
| SCHEMBL3251568 | 0.82 | PARG (0.48) | PARGTDP1KDM4EHTTPOLB | |
| SCHEMBL3243012 | 0.81 | PARG (0.56) | PARGTDP1KDM4EHTTPOLB | |
| SCHEMBL3242536 | 0.79 | TDP1 (0.53) | PARGTDP1KDM4EPOLBMAPT | |
| SCHEMBL3242728 | 0.78 | KDM4E (0.45) | KDM4EHTTPOLBHSD17B10MEN1 | |
| SCHEMBL3242979 | 0.78 | KDM4E (0.45) | KDM4EHTTPOLBHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |