Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247678 | 0.92 | TSHR (0.53) | MAPK1KMT2AALDH1A1TP53LMNA | |
| SCHEMBL3244779 | 0.91 | MEP1B (0.46) | MAPK1KMT2AALDH1A1TP53LMNA | |
| SCHEMBL3256172 | 0.90 | HTT (0.48) | MAPK1KMT2AALDH1A1TP53LMNA | |
| SCHEMBL4872129 | 0.89 | TSHR (0.48) | MAPK1KMT2AALDH1A1TP53LMNA | |
| SCHEMBL3244635 | 0.89 | MEP1B (0.46) | MAPK1KMT2AALDH1A1TP53LMNA | |
| SCHEMBL3251279 | 0.88 | KMT2A (0.48) | MAPK1KMT2AALDH1A1TP53LMNA | |
| SCHEMBL3252098 | 0.87 | TSHR (0.49) | MAPK1KMT2AALDH1A1TP53LMNA | |
| SCHEMBL3254822 | 0.87 | MEP1B (0.51) | MAPK1KMT2AALDH1A1TP53LMNA | |
| SCHEMBL3252883 | 0.86 | TSHR (0.48) | MAPK1KMT2AALDH1A1TP53LMNA | |
| SCHEMBL3252885 | 0.86 | MEP1B (0.49) | MAPK1KMT2AALDH1A1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776347-B1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI AVENTIS (FR) | 2010-05-26 | — | — | EP | disclosed |
| US-7396958-B2 | Sulphonamide derivatives, their preparation and their therapeutic application | SANOFI AVENTIS (FR) | 2008-07-08 | — | — | US | disclosed |