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Sugi Predict / Targets / MEP1B

MEP1B

Meprin A subunit beta · Q16820 · MEP1B on Sugi Atlas →

11,595 patent compounds predicted against MEP1B, 6,715 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1456846 SCHEMBL1456846 0.60 13/20
SCHEMBL805218 SCHEMBL805218 0.59 11/20
SCHEMBL168738 SCHEMBL168738 0.58 11/20
SCHEMBL1402743 SCHEMBL1402743 0.46 11/20
SCHEMBL1771503 SCHEMBL1771503 0.64 7/20
SCHEMBL391212 SCHEMBL391212 0.57 7/20
SCHEMBL791813 SCHEMBL791813 0.48 7/20
SCHEMBL1638524 SCHEMBL1638524 0.55 6/20
SCHEMBL40108 SCHEMBL40108 0.51 6/20
SCHEMBL557761 SCHEMBL557761 0.51 6/20
SCHEMBL646717 SCHEMBL646717 0.49 6/20
SCHEMBL184425 SCHEMBL184425 0.50 5/20
SCHEMBL1674832 SCHEMBL1674832 0.45 5/20
SCHEMBL1230893 SCHEMBL1230893 0.40 5/20
SCHEMBL211138 SCHEMBL211138 0.61 4/20
SCHEMBL1287315 SCHEMBL1287315 0.56 4/20
SCHEMBL1363798 SCHEMBL1363798 0.56 4/20
SCHEMBL1411164 SCHEMBL1411164 0.55 4/20
SCHEMBL848969 SCHEMBL848969 0.52 4/20
SCHEMBL1147679 SCHEMBL1147679 0.50 4/20

Clinical trials — most relevant to MEP1B by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Peptide Vaccine Focusing on Prevention of the Recurrence for Bladder Cancer PHASE2UNKNOWN
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Novel Peptide Vaccination for Patients With Advanced Bladder Cancer PHASE1COMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
MEHMO Natural History and Biomarkers nanRECRUITING
Rett Syndrome Registry nanRECRUITING
Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks nanRECRUITING
Hydroxychloroquin (HCQ) in chILD of Genetic Defect nanCOMPLETED
Signs and Symptoms of Genetic Abnormalities Linked to Inherited Heart Disease nanCOMPLETED
Human Epilepsy Genetics--Neuronal Migration Disorders Study nanRECRUITING
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) nanRECRUITING
Genetics and Psychopathology in the 22q11 Deletion Syndrome nanUNKNOWN
Exploring the Genetics of Neuropathic Pain nanRECRUITING
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome nanACTIVE_NOT_RECRUITING
Genetic Identification of Monogenic Disorders in Early-onset Stroke Using Targeted Next Generation Sequencing Panel nanCOMPLETED
Identification of an Asthma Susceptibility Gene on 3P nanCOMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits nanCOMPLETED
Study of Constitutional Platelet Disease nanUNKNOWN
Registry Gangliosidoses nanUNKNOWN
Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA nanRECRUITING
Predictors of Drug Resistant Epilepsy Among Pediatric Patients nanNOT_YET_RECRUITING
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development nanCOMPLETED
The Natural History of Alpha-Mannosidosis nanCOMPLETED
Defining the Brain Phenotype of Children With Williams Syndrome nanRECRUITING
Susceptibility Genes in Autism Spectrum Disorders nanCOMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
Phenotype/Genotype Correlations in Neuromuscular Disorders nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a MEP1B binder may also engage these)

ProteinNameSimilarity
Q61847 — 1.000 Q61847 →
P28826 — 1.000 P28826 →
P28825 — 0.990 P28825 →
Q64230 — 0.987 Q64230 →
PTPRM Receptor-type tyrosine-protein phosphatase mu 0.987 landscape →
Q7JLI1 — 0.987 Q7JLI1 →
P91828 — 0.986 P91828 →
Q20958 — 0.986 Q20958 →
Q20176 — 0.985 Q20176 →
EPHA6 Ephrin type-A receptor 6 0.985 landscape →
Q90344 — 0.985 Q90344 →
O77633 — 0.984 O77633 →
Q07498 — 0.984 Q07498 →
EPHA3 Ephrin type-A receptor 3 0.984 landscape →
Q91735 — 0.984 Q91735 →
Q60629 — 0.984 Q60629 →
Q8JZZ7 — 0.984 Q8JZZ7 →
O73798 — 0.984 O73798 →
P57748 — 0.983 P57748 →
D5FM34 — 0.983 D5FM34 →
D5FM37 — 0.983 D5FM37 →
Q9GYQ4 — 0.983 Q9GYQ4 →
Q22710 — 0.983 Q22710 →
Q80ZA4 — 0.983 Q80ZA4 →
O88917 — 0.983 O88917 →
ADAM10 Disintegrin and metalloproteinase domain-containing protein 10 0.983 landscape →
O17264 — 0.983 O17264 →
Q10741 — 0.983 Q10741 →
Q22396 — 0.983 Q22396 →
O42422 — 0.983 O42422 →