Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924294 | 0.87 | POLB (0.40) | POLBSMN1; SMN2ALDH1A1NLRP3BRD4 | |
| SCHEMBL3256241 | 0.84 | AURKA (0.39) | POLBSMN1; SMN2ALDH1A1NLRP3CYP1A2 | |
| SCHEMBL2920137 | 0.78 | NR1H4 (0.42) | POLBAPOBEC3AAPOBEC3GKMT2ATP53 | |
| SCHEMBL3257708 | 0.75 | MAPK1 (0.35) | POLBSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL3243651 | 0.74 | EPHX1 (0.37) | SMN1; SMN2ALDH1A1CYP3A4CYP2C19TP53 | |
| SCHEMBL2924288 | 0.74 | CCNA2 (0.42) | POLBSMN1; SMN2ALDH1A1NLRP3CYP1A2 | |
| SCHEMBL2920141 | 0.65 | AURKA (0.54) | TP53RAB9A | |
| SCHEMBL3134595 | 0.64 | HPGD (0.48) | POLBSMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL4238899 | 0.64 | CDK2 (0.42) | ALDH1A1NPC1 | |
| SCHEMBL2924353 | 0.64 | EPHX1 (0.40) | SMN1; SMN2ALDH1A1KMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-B1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-09-08 | — | — | EP | claimed |