Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 4/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924288 | 0.87 | CCNA2 (0.42) | AURKACCNA2CDK2CCNA1MEN1 | |
| SCHEMBL3256238 | 0.84 | POLB (0.39) | MEN1KMT2APOLBCYP1A2CYP3A4 | |
| SCHEMBL2920141 | 0.78 | AURKA (0.54) | AURKACCNA2CDK2CCNA1TP53 | |
| SCHEMBL3257712 | 0.76 | CCNA2 (0.40) | CCNA2CDK2CCNA1MEN1KMT2A | |
| SCHEMBL3243655 | 0.74 | EPHX1 (0.38) | RAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2924294 | 0.74 | POLB (0.40) | CCNA2CDK2MEN1KMT2APOLB | |
| SCHEMBL2920137 | 0.65 | NR1H4 (0.42) | AURKACCNA2CDK2CCNA1MEN1 | |
| SCHEMBL3134607 | 0.65 | CDK2 (0.59) | AURKACCNA2CDK2CCNA1RAB9A | |
| SCHEMBL2919875 | 0.65 | CCNA2 (0.46) | AURKACCNA2CDK2CCNA1MEN1 | |
| SCHEMBL4238904 | 0.64 | CDK2 (0.58) | AURKACCNA2CDK2CCNA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-B1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-09-08 | — | — | EP | claimed |