Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253085 | 0.91 | GPR119 (0.59) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3246678 | 0.91 | GPR119 (0.58) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3255562 | 0.90 | GPR119 (0.58) | GPR119CYP2C9KCNH2 | |
| SCHEMBL386643 | 0.90 | GPR119 (0.77) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3253294 | 0.89 | GPR119 (0.61) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3258278 | 0.89 | GPR119 (0.48) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3246517 | 0.88 | GPR119 (0.80) | GPR119CYP2C9KCNH2 | |
| SCHEMBL391626 | 0.87 | GPR119 (0.70) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3142957 | 0.87 | GPR119 (0.70) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3248519 | 0.86 | GPR119 (0.57) | GPR119CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1911756-B9 | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto | ARENA PHARM INC (US) | 2010-05-26 | — | — | EP | claimed |
| EP-1911756-B1 | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto | ARENA PHARM INC (US) | 2009-10-21 | — | — | EP | claimed |
| EP-1732562-B1 | SUBSTITUTED PYRIDINYL AND PYRIMIDINYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2007-12-19 | — | — | EP | claimed |