Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 2/20 | 0.70 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.70 |
| ▸ | PLK4 | O00444 | 1/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.70 |
| ▸ | AURKA | O14965 | 1/20 | 0.70 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.70 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.70 |
| ▸ | CDK1 | P06493 | 1/20 | 0.70 |
| ▸ | PIM1 | P11309 | 1/20 | 0.70 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.70 |
| ▸ | FLT4 | P35916 | 1/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.70 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.70 |
| ▸ | GSK3A | P49840 | 1/20 | 0.70 |
| ▸ | GSK3B | P49841 | 1/20 | 0.70 |
| ▸ | JAK3 | P52333 | 1/20 | 0.70 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.70 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.70 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3257680 | 0.86 | NPC1 (0.58) | MAPK9CSNK2A1PLK4CHEK1AURKA | |
| SCHEMBL18511359 | 0.79 | GAA (0.63) | MAPK9CSNK2A1PLK4CHEK1AURKA | |
| SCHEMBL29572859 | 0.79 | RAB9A (1.00) | MAPK9CSNK2A1PLK4CHEK1AURKA | |
| SCHEMBL278729 | 0.79 | RAB9A (1.00) | MAPK9CSNK2A1PLK4CHEK1AURKA | |
| SCHEMBL3257613 | 0.78 | DYRK1A (0.48) | MAPK9CSNK2A1PLK4CHEK1AURKA | |
| SCHEMBL8832011 | 0.77 | NPC1 (0.71) | MAPK9CSNK2A1PLK4CHEK1AURKA | |
| SCHEMBL8832035 | 0.77 | NPC1 (0.71) | MAPK9CSNK2A1PLK4CHEK1AURKA | |
| SCHEMBL2251936 | 0.75 | TDP1 (0.71) | MAPTRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL2251523 | 0.75 | TDP1 (0.71) | MAPTRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL278691 | 0.75 | NPC1 (0.72) | MAPK9CSNK2A1PLK4CHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2128160-B1 | Indolo[2,3-b]-, Indeno[1,2-b]- and Indeno[2,1-b]pyrido[2,3-f] quinoxaline-3-carboxylic acids and esters, processes for their preparation and their use as antiviral, antibiotic and antitumor agents | UNIV DUISBURG ESSEN (DE) | 2010-07-14 | — | — | EP | disclosed |
| EP-2128160-A1 | Indolo[2,3-b]-, Indeno[1,2-b]- and Indeno[2,1-b]pyrido[2,3-f] quinoxaline-3-carboxylic acids and esters, processes for their preparation and their use as antiviral, antibiotic and antitumor agents | Universität Duisburg-Essen (DE) | 2009-12-02 | — | — | EP | disclosed |