Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 17/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 4/20 | 0.42 |
| ▸ | PLA2G5 | P39877 | 4/20 | 0.42 |
| ▸ | PLA2G2E | Q9NZK7 | 4/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.42 |
| ▸ | PLA2G2F | Q9BZM2 | 2/20 | 0.41 |
| ▸ | PLA2G2D | Q9UNK4 | 2/20 | 0.41 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.41 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.41 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.41 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.41 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL818181 | 0.91 | PLA2G2A (0.52) | PLA2G2APLA2G10PLA2G5PLA2G2EPLA2G1B | |
| SCHEMBL29862616 | 0.91 | PLA2G2A (0.52) | PLA2G2APLA2G10PLA2G5PLA2G2EPLA2G1B | |
| SCHEMBL6693386 | 0.90 | PLA2G2A (0.51) | PLA2G2APLA2G10PLA2G5PLA2G2EPLA2G1B | |
| SCHEMBL6693400 | 0.90 | PLA2G2A (0.51) | PLA2G2APLA2G10PLA2G5PLA2G2EPLA2G1B | |
| SCHEMBL6693389 | 0.88 | PLA2G2A (0.54) | NPC1TP53RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6695139 | 0.88 | PLA2G2A (0.51) | PLA2G2APLA2G10 | |
| SCHEMBL5208128 | 0.88 | PLA2G2A (0.55) | PLA2G2APLA2G10PLA2G5PLA2G2EPLA2G1B | |
| SCHEMBL6692869 | 0.86 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G5PLA2G2EPLA2G1B | |
| SCHEMBL6610906 | 0.86 | PLA2G2A (0.52) | PLA2G2APLA2G10PLA2G5PLA2G2EPLA2G1B | |
| SCHEMBL818332 | 0.85 | PLA2G2A (0.41) | NPC1TP53RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2154958-A1 | TREATMENT OF CARDIOVASCULAR DISEASE AND DYSLIPIDEMIA USING SECRETORY PHOSPHOLIPASE A2 (SPLA2) INHIBITORS AND SPLA2 INHIBITOR COMBINATION THERAPIES | Anthera Pharmaceuticals, Inc. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008137803-A1 | TREATMENT OF CARDIOVASCULAR DISEASE AND DYSLIPIDEMIA USING SECRETORY PHOSPHOLIPASE A2 (SPLA2) INHIBITORS AND SPLA2 INHIBITOR COMBINATION THERAPIES | ANTHERA PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |