Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL217180 | 0.80 | ALDH1A1 (0.38) | ALDH1A1LMNAHSD17B10GAATSHR | |
| SCHEMBL27338320 | 0.78 | ALDH1A1 (0.33) | ALDH1A1TSHR | |
| SCHEMBL8740167 | 0.76 | HCAR2 (0.35) | TSHR | |
| SCHEMBL8740170 | 0.76 | HCAR2 (0.35) | TSHR | |
| SCHEMBL4450445 | 0.76 | TSHR (0.36) | ALDH1A1LMNAHSD17B10GAATSHR | |
| SCHEMBL27338272 | 0.76 | CYP1A2 (0.32) | TSHRCYP1A2CYP2D6CYP2C19 | |
| Trimethylammonium SCHEMBL27614440 | 0.75 | ALDH1A1 (0.33) | ALDH1A1LMNAHSD17B10GAATSHR | |
| SCHEMBL583100 | 0.75 | TSHR (0.30) | TSHR | |
| SCHEMBL1584536 | 0.74 | GAA (0.48) | ALDH1A1LMNAHSD17B10GAATSHR | |
| SCHEMBL9639669 | 0.73 | TSHR (0.43) | ALDH1A1LMNAHSD17B10GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-B1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-07-21 | — | — | EP | disclosed |
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |