Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254513 | 0.91 | SMN1; SMN2 (0.36) | DHFRSMN1; SMN2MEN1SLC22A1ALDH1A1 | |
| SCHEMBL3248631 | 0.91 | SMN1; SMN2 (0.36) | DHFRSMN1; SMN2MEN1SLC22A1ALDH1A1 | |
| SCHEMBL3254448 | 0.89 | DHFR (0.39) | DHFRSMN1; SMN2MEN1SLC22A1ALDH1A1 | |
| SCHEMBL3258062 | 0.88 | DHFR (0.40) | DHFRSMN1; SMN2MEN1SLC22A1ALDH1A1 | |
| SCHEMBL3258019 | 0.88 | DHFR (0.40) | DHFRSMN1; SMN2MEN1SLC22A1ALDH1A1 | |
| SCHEMBL3258152 | 0.84 | SMN1; SMN2 (0.41) | DHFRSMN1; SMN2MEN1SLC22A1ALDH1A1 | |
| SCHEMBL3257418 | 0.83 | DHFR (0.39) | DHFRSMN1; SMN2MEN1SLC22A1ALDH1A1 | |
| SCHEMBL3252735 | 0.83 | DHFR (0.45) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL3254454 | 0.82 | SMN1; SMN2 (0.39) | DHFRSMN1; SMN2MEN1SLC22A1ALDH1A1 | |
| SCHEMBL3251639 | 0.80 | SMN1; SMN2 (0.37) | DHFRSMN1; SMN2MEN1SLC22A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651639-B1 | BENZOFURAN DERIVATIVES AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTIONS | ARPIDA AG (CH) | 2010-05-26 | — | — | EP | claimed |