Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.47 |
| ▸ | AR | P10275 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.44 |
| ▸ | VEGFA | P15692 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550179 | 0.83 | AR (0.60) | EGFRERBB2ERBB3ERBB4EPAS1 | |
| SCHEMBL2747584 | 0.82 | EGFR (0.50) | EGFRERBB2ERBB3ERBB4EPAS1 | |
| SCHEMBL30442130 | 0.82 | EPAS1 (0.47) | EGFRERBB2ERBB3ERBB4EPAS1 | |
| SCHEMBL25331897 | 0.82 | EPAS1 (0.47) | EGFRERBB2ERBB3ERBB4EPAS1 | |
| SCHEMBL920869 | 0.81 | AR (0.54) | EGFRERBB2ERBB3ERBB4EPAS1 | |
| SCHEMBL2749527 | 0.77 | MEN1 (0.58) | EPAS1 | |
| SCHEMBL4171609 | 0.77 | AR (0.70) | EGFRERBB2ERBB3ERBB4AR | |
| SCHEMBL11088375 | 0.77 | AR (0.54) | EGFRERBB2ERBB3ERBB4EPAS1 | |
| SCHEMBL10088434 | 0.76 | AR (0.65) | ARCYP19A1MRGPRX4KCNH2SLC6A4 | |
| SCHEMBL8432193 | 0.76 | AR (0.55) | EPAS1ARCYP19A1VEGFASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036917-A1 | PREVENTION AND TREATMENT OF CANCER WITH RAS GENE MUTATION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010036910-A1 | HEART PROTECTION BY ADMINISTERING AN AMP-ACTIVATED PROTEIN KINASE ACTIVATOR | OHTA YOSHIKAZU (JP) | 2010-04-01 | — | — | WO | disclosed |