Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.74 |
| ▸ | BRD4 | O60885 | 7/20 | 0.57 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.56 |
| ▸ | CLK2 | P49760 | 3/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.56 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.56 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.56 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.56 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.56 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.56 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.56 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | FES | P07332 | 2/20 | 0.56 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.56 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.56 |
| ▸ | NEK2 | P51955 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3261508 | 0.93 | PLK1 (0.75) | PLK1BRD4PLK3PRKD3CLK2 | |
| SCHEMBL3261988 | 0.93 | PLK1 (0.74) | PLK1BRD4PLK3PTK2PLK2 | |
| SCHEMBL3264165 | 0.91 | PLK1 (0.74) | PLK1BRD4PLK3PLK2 | |
| SCHEMBL3262896 | 0.89 | PLK1 (0.77) | PLK1BRD4PLK3PTK2PLK2 | |
| SCHEMBL3262527 | 0.87 | PLK1 (0.74) | PLK1BRD4PLK3PTK2PLK2 | |
| SCHEMBL3259963 | 0.86 | PLK1 (0.78) | PLK1PLK3PLK2 | |
| SCHEMBL3261587 | 0.84 | PLK1 (0.75) | PLK1PLK3PLK2 | |
| SCHEMBL3259080 | 0.84 | PLK1 (0.81) | PLK1BRD4PLK3PRKD3CLK2 | |
| SCHEMBL3265448 | 0.83 | PLK1 (0.75) | PLK1BRD4PLK3PLK2 | |
| SCHEMBL3261372 | 0.83 | PLK1 (0.94) | PLK1BRD4PLK3PRKD3CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010025073-A1 | DIHYDROIMIDAZO [ 1, 5-F] PTERIDINES AS POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-04 | — | — | WO | disclosed |