Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.77 |
| ▸ | BRD4 | O60885 | 5/20 | 0.57 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.52 |
| ▸ | PDXK | O00764 | 1/20 | 0.52 |
| ▸ | WEE1 | P30291 | 1/20 | 0.52 |
| ▸ | NEK3 | P51956 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.52 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.52 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3261988 | 0.96 | PLK1 (0.74) | PLK1BRD4BRDTPDXKWEE1 | |
| SCHEMBL3262527 | 0.96 | PLK1 (0.74) | PLK1BRD4BRDTPDXKWEE1 | |
| SCHEMBL3265579 | 0.90 | PLK1 (0.77) | PLK1BRD4BRDTPDXKWEE1 | |
| SCHEMBL3260798 | 0.90 | PLK1 (0.78) | PLK1BRD4BRDTPDXKWEE1 | |
| SCHEMBL3260801 | 0.90 | PLK1 (0.78) | PLK1BRD4BRDTPDXKWEE1 | |
| SCHEMBL3259082 | 0.89 | PLK1 (0.74) | PLK1BRD4BRDTPDXKNEK3 | |
| SCHEMBL3261508 | 0.87 | PLK1 (0.75) | PLK1BRD4BRDTPDXKNEK3 | |
| SCHEMBL3265448 | 0.86 | PLK1 (0.75) | PLK1BRD4PLK3PLK2 | |
| SCHEMBL3260121 | 0.86 | PLK1 (0.74) | PLK1BRD4BRDTPDXKWEE1 | |
| SCHEMBL3262895 | 0.85 | PLK1 (0.83) | PLK1BRD4BRDTPDXKWEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010025073-A1 | DIHYDROIMIDAZO [ 1, 5-F] PTERIDINES AS POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-04 | — | — | WO | disclosed |