Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 8/20 | 0.46 |
| ▸ | AKT2 | P31751 | 3/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | PRKCB | P05771 | 2/20 | 0.46 |
| ▸ | PRKCA | P17252 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | PRKACB | P22694 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302178 | 0.81 | AKT1 (0.56) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL2300062 | 0.81 | AKT1 (0.56) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL2301203 | 0.81 | AKT1 (0.56) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL2304468 | 0.79 | AKT1 (0.44) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL12423936 | 0.78 | AKT1 (0.43) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL2301031 | 0.76 | AKT1 (0.49) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL4543909 | 0.75 | HDAC8 (0.39) | AKT1ALDH1A1CYP3A4HPGD | |
| SCHEMBL4541109 | 0.73 | AKT1 (0.53) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL2300200 | 0.73 | AKT1 (0.56) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL2302980 | 0.73 | AKT1 (0.56) | AKT1AKT2AKT3ROCK2PRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045309-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-04-22 | — | — | WO | disclosed |