Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 9/20 | 0.53 |
| ▸ | AKT2 | P31751 | 4/20 | 0.53 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | PRKCB | P05771 | 2/20 | 0.53 |
| ▸ | PRKCA | P17252 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | PRKACB | P22694 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.53 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543991 | 0.93 | AKT1 (0.45) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL4543363 | 0.88 | AKT1 (0.39) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL3509203 | 0.84 | AKT1 (0.58) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL3509207 | 0.84 | AKT1 (0.58) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL1529486 | 0.84 | AKT1 (0.71) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL12679218 | 0.84 | AKT1 (0.61) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL4379890 | 0.82 | AKT1 (0.43) | AKT1AKT2AKT3MCL1 | |
| SCHEMBL1530242 | 0.81 | AKT1 (0.55) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL1530240 | 0.81 | AKT1 (0.55) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL12679246 | 0.79 | AKT1 (0.54) | AKT1AKT2AKT3ROCK2PRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |